The show won the 2008 Gemini Award for "Best Talk Series".
After beginning as a show that featured performances, interviews, stories on musicians, and focused on music, the show has become dedicated to focusing on its hosts, with little musical content.
The band was supposed to play three songs, but were stopped midway through the second song as MTV was not aware of the destruction the band had planned and were concerned about the safety of the band, audience, and crew.
Some audience members had hidden in separate areas of the studio, due to fear.
In early 2008, the show began to shoot in different areas of the studio and was updated by designer Adam Nathan, who also designed the set for The After Show.
MTV hosts also used to appear in short segments known as Quick Chats, which were seen during regular MTV programming.
This time the band performed in the men's washroom.
The hosts were often joined by viewers via webcam, phone, or through email submissions. Previous guests include MTV reality star Tila Tequila, Canadian dancer Blake Mc Grath, reality TV regular Evan Starkman and bands such as Moneen, The Most Serene Republic, ill Scarlett, and Alexisonfire.
Active from 2007–2008, every Friday the best moments of the week from MTV Live and MTV News were edited into a one-hour program called MTV Shuffle. Hacked was an interactive chat which viewers participate in through MTV Hive.
Daily Dancer, a regular webcam guest in 2006, also appeared in the launch episode.
The show shared its official on-air launch party with MTV Canada as a channel on April 18, 2006, with live performances by Kanye West and Sam Roberts. Starting in mid-May 2006, the show started using two hosts for each MTV Live episode, with Daryn Jones acting as the primary host with alternating co-hosts Jessi Cruickshank, Nicole Holness, Dan Levy, and Aliya-Jasmine Sovani.